The concomitant use of alcohol or other central nervous system depressants, including narcotic analgesics, sedatives, hypnotics, and tranquilizers, may have an additive effect and should be avoided or their dosage reduced. severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out. Activated charcoal orally or by lavage may be given, or sodium or magnesium sulfate orally as a cathartic. It is often recommended to start within the first 1 or 2 hours of a meal and to take the medication with food. Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Administration of promethazine has been associated with reported cholestatic jaundice. Drug Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever and primary central nervous system (CNS) pathology. Drug Should I avoid certain foods while taking Promethazine VC Plain Syrup? Promethazine administered to a pregnant woman within two weeks of delivery may inhibit platelet aggregation in the newborn. Signs of a friend or loved one going through a promethazine codeine overdose include: The person will be extremely drowsy. Promethazine HCl is a racemic compound; the empirical formula is C 17 H 20 N 2 SHCl and its molecular weight is 320.88. Promethazine is well absorbed from the gastrointestinal tract. News; Reviews; Features. Check the label to see if a medicine contains an antihistamine or decongestant. The generic name of Promethazine Vc is promethazine hydrochloride and phenylephrine hydrochloride. Do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. High price from $0.72 for tablet promethazine 25 mg with Visa. In pediatric patients who are acutely ill associated with dehydration, there is an increased susceptibility to dystonias with the use of promethazine HCl. A direct action at receptors accounts for the greater part of its effects, only a small part being due to its ability to release norepinephrine. Another study showed that phenylephrine was associated with anomalies of aortic arch and with ventricular septal defect in the chick embryo. A paradoxical reaction has been reported in children receiving single doses of 75 mg to 125 mg orally, characterized by hyperexcitability and nightmares. The treatment of overdosage with promethazine and phenylephrine is essentially symptomatic and supportive. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Local vasoconstriction and hemostasis occur following topical application or infiltration of phenylephrine into tissues. Clinical effects are apparent within 20 minutes after oral administration and generally last four to six hours, although they may persist as long as 12 hours. Drug ANTIEMETICS ARE NOT RECOMMENDED FOR TREATMENT OF UNCOMPLICATED VOMITING IN PEDIATRIC PATIENTS, AND THEIR USE SHOULD BE LIMITED TO PROLONGED VOMITING OF KNOWN ETIOLOGY. This medication may make you more sensitive to the sun. EffectPressor response decreased. Phenylephrine should be used with caution in patients with cardiovascular disease, particularly hypertension. Effect CRUMBS ISSUE #100. There are no adequate and well-controlled studies of promethazine in pregnant women. Promethazine HCl, a phenothiazine derivative, is designated chemically as 10 H -Phenothiazine-10-ethanamine, N, N, -trimethyl-, monohydrochloride, ()- with the following structural formula: Promethazine HCl occurs as a . Huntsville, AL 35811, Relabeled By: Tell your doctor if your condition lasts for more than 1 week, if it gets worse, or if it occurs with a headache that doesn't go away, fever, or rash. Promethazine hydrochloride occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air. Children may be more sensitive to the side effects of this drug, especially slowed breathing and uncontrolled movements (See also Warning section). Phenylephrine with prior administration of propranolol or other -adrenergic blockers. Phenylephrine should be used with caution in patients taking diet preparations, such as amphetamines or phenylpropanolamine, because synergistic adrenergic effects could result in serious hypertensive response and possible stroke. Avoid analeptics which may cause convulsions. Promethazine is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Phenylephrine is contraindicated in patients with hypertension or with peripheral vascular insufficiency (ischemia may result with risk of gangrene or thrombosis of compromised vascular beds). promethazine syrup of top notch quality from the comfort of your couch and become one of our happy clients with satisfaction. Para que sirve el promethazine codeine syrup. Phenylephrine is a potent postsynaptic -receptor agonist with little effect on -receptors of the heart. Liquid forms of this medication may contain sugar, alcohol, or aspartame. Their skin color may change. Phenylephrine with bronchodilator sympathomimetic agents and with epinephrine or other sympathomimetics. Promethazine may lead to potentially fatal respiratory depression. Average: 4.83 5.00, 300 reviews Leukopenia and agranulocytosis have been reported, usually when promethazine HCl has been used in association with other known marrow toxic agents. Concomitant use of other agents with anticholinergic properties should be undertaken with caution. Promethazine VC can make you very sleepy and should not be used in children younger than 2 years old or in people with certain heart or breathing problems. Fasted from $0.72 per dose promethazine 25 mg best quality guaranteed prescription. and untreated or inadequately treated extrapyramidal signs and symptoms (EPS). Hi everybody: maybe someone has experience with promethazine plain syrup prescribed for cough. Jarabe de Promethazina Dm / Promethazine DM Syrup puede interactuar con los siguientes frmacos y productos: Promethazine hydrochloride and phenylephrine hydrochloride oral solution is contraindicated for children under 2 years of age (see WARNINGS Black Box Warning and Use In Pediatric Patients). la prometazina se usa para aliviar los sntomas de reacciones alrgicas como la rinitis alrgica (secrecin nasal y lagrimeo de ojos causados por la alergia al polen, al moho o al polvo), conjuntivitis alrgica (enrojecimiento, lagrimeo de ojos causados por las alergias), reacciones alrgicas de la piel, y reacciones alrgicas a la sangre o los All rights reserved. You should not use this medicine if you are allergic to phenylephrine or promethazine, or if you have: To make sure Promethazine VC Plain is safe for you, tell your doctor if you have: sleep apnea (breathing stops during sleep); severe constipation, a blockage in your stomach or intestines; pheochromocytoma (an adrenal gland tumor); or. . Do not take Promethazine VC Plain in larger or smaller amounts or for longer than recommended. Does Promethazine VC Plain Syrup interact with other medications? Take from $0.72 for 1 tablet promethazine 25 mg MasterCard. Acidosis and electrolyte losses should be corrected. Signs and symptoms of overdosage with phenylephrine include hypertension, headache, convulsions, cerebral hemorrhage, and vomiting. Nervous System Restlessness, anxiety, nervousness, and dizziness. Drug class: Upper respiratory combinations. THE USE OF PROMETHAZINE PRODUCTS SHOULD BE AVOIDED IN PEDIATRIC PATIENTS WHOSE SIGNS AND SYMPTOMS MAY SUGGEST REYE'S SYNDROME OR OTHER HEPATIC DISEASES. Following oral administration, nasal decongestion may occur within 15 or 20 minutes and may persist for up to 4 hours. Store at 20 to 25C (68 to 77F) [See USP Controlled Room Temperature]. Dosage form: oral solution (PROMETHAZINE PHENYLEPHRINE HYDROCHLORIDE ORAL SOLUTION. Ask your doctor or pharmacist about using this product safely. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmias). Local vasoconstriction and hemostasis occur following topical application or infiltration of phenylephrine into tissues. Promethazine is well absorbed from the gastrointestinal tract. These doses are from approximately 2.1 to 4.2 times the maximum recommended total daily dose of promethazine for a 50-kg subject, depending upon the indication for which the drug is prescribed. Promethazine codeine taken off market buy online Canada. Promethazine and phenylephrine may cause marked drowsiness or may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery. inflammation of the nose due to an allergy, non-seasonal allergic stuffy and runny nose. Limit your time in the sun. A WIDE RANGE OF WEIGHT-BASED DOSES OF PROMETHAZINE HYDROCHLORIDE HAVE RESULTED IN RESPIRATORY DEPRESSION IN THESE PATIENTS. It has a molecular weight of 320.88, a molecular formula of C17H20N2SHCI, and the following structural formula: Phenylephrine hydrochloride is a sympathomimetic amine salt which is chemically designated as (-)-m-Hydroxy--[(methylamino)methyl] benzyl alcohol hydrochloride. Cardiac pressor response potentiated. Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations. Sedation, somnolence, blurred vision, dizziness; confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. Be careful if you drive or do anything that requires you to be alert and able to see clearly. PA 19107 USA Contact 24/7 (00:00 - 00:00) +1(276) 565-8108; BUY PROMETHAZINE COUGH SYRUP ONLINE . Excessive rise in blood pressure. What is phenylephrine and promethazine (Phenergan VC, Promethazine VC, Promethazine VC Plain)? Do not give this medicine to a child younger than 2 years old. Hallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine hydrochloride in pediatric patients. Note that any depressant effects of promethazine are not reversed by naloxone. 1.promethazine-DM 6.25 mg-15 mg/5 mL oral syrup; 2.Promethazine DM Informacin Espaola De la Droga - Drugs.com; 3.Promethazine with DM Informacin Espaola De la Droga - Drugs.com; 4.dextromethorphan and promethazine - Cigna; 5.promethazine (oral) - Cigna; 6.Promethazine dm syrup para que sirve - over the counter substitute Promethazine hydrochloride and phenylephrine hydrochloride syrup is indicated for the temporary relief of upper respiratory symptoms, including nasal congestion, associated with allergy or the common cold. This preparation is a yellow-orange colored, fruit-flavored syrup. It is not known whether this drug combination can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. RESPIRATORY DEPRESSION AND APNEA, SOMETIMES ASSOCIATED WITH DEATH, ARE STRONGLY ASSOCIATED WITH PROMETHAZINE PRODUCTS AND ARE NOT DIRECTLY RELATED TO INDIVIDUALIZED WEIGHT-BASED DOSING, WHICH MIGHT OTHERWISE PERMIT SAFE ADMINISTRATION. THE USE OF PROMETHAZINE PRODUCTS SHOULD BE AVOIDED IN PEDIATRIC PATIENTS WHOSE SIGNS AND SYMPTOMS MAY SUGGEST REYE'S SYNDROME OR OTHER HEPATIC DISEASES. (See WARNINGS Promethazine;Neuroleptic Malignant Syndrome.). Ask your doctor before taking Promethazine VC Plain with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures. Version: 4.01. Use of promethazine in patients with compromised respiratory function (e.g., COPD, sleep apnea) should be avoided. Phenylephrine increases resistance and, to a lesser extent, decreases capacitance of blood vessels. This medication may be taken with food if stomach upset occurs. If you are taking the medication regularly, take the missed dose as soon as you remember. Inactive Ingredients: Apricot peach flavor, ascorbic acid, citric acid, FD&C yellow #6, menthol, methylparaben, propylene glycol, propylparaben, purified water, saccharin sodium, sodium benzoate, sodium citrate and sucrose. A WIDE RANGE OF WEIGHT-BASED DOSES OF PROMETHAZINE HYDROCHLORIDE HAVE RESULTED IN RESPIRATORY DEPRESSION IN THESE PATIENTS. Promethazine is contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines. Promethazine may lower seizure threshold. Promethazine and phenylephrine may cause marked drowsiness or may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery. Available for Android and iOS devices. Adaptations and alternatives that offer comparisons by cancer or with undiagnosed HIV infections and vaccinations. Only in cases of extreme overdosage or individual sensitivity do vital signs including respiration, pulse, blood pressure, temperature, and EKG need to be monitored. It may also help with some symptoms associated with the common cold [4] and may also be used for sedating people who are agitated or anxious, an effect that has led to some recreational use ( especially with codeine ). Promethazine and phenylephrine should be given to a pregnant woman only if clearly needed. Drug Effect Area guides; Best of; Interviews; Drinks; Hip shops; Recipes; Events; More. Promethazine hydrochloride occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air. Children should be supervised to avoid potential harm in bike riding or in other hazardous activities. Following oral administration or topical application of phenylephrine to the mucosa, constriction of blood vessels in the nasal mucosa relieves nasal congestion associated with allergy or head colds. We comply with the HONcode standard for trustworthy health information. There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Sedating drugs may cause confusion and over-sedation in the elderly; elderly patients generally should be started on low doses of promethazine hydrochloride and phenylephrine hydrochloride syrup and observed closely. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). EffectCardiostimulating effects blocked. Drink plenty of fluids when you use this medication unless otherwise directed by your doctor. Preferred Pharmaceuticals, Inc. Each 5 mL (one teaspoonful), for oral administration contains: Promethazine hydrochloride 6.25 mg; phenylephrine hydrochloride 5 mg. Alcohol 7%. Lowest prices on $0.72 for 1 pill promethazine 25 mg OVERNIGHT SHIPPING. Paradoxical Reactions Hyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine HCI. It is unknown if this medication passes into breast milk. Phenylephrine hydrochloride is subject to oxidation and must be protected from light and air. to teaspoonful (1.25 to 2.5 mL) every 4 to 6 hours. Phenylephrine is a potent postsynaptic -receptor agonist with little effect on -receptors of the heart. Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. Tell your doctor if your condition does not appear to be getting better or if it gets worse. Severe hypotension usually responds to the administration of norepinephrine or phenylephrine. buy promethazine syrup online Skip to content. to 1 teaspoonful (2.5 to 5 mL) every 4 to 6 hours, not to exceed 6 teaspoonsful (30 mL) in 24 hours. EffectPressor response increased. Warnings Do not give Promethazine VC Plain to a child younger than 2 years old. They will experience a weakness in their muscles. It has about 1/10 the antipsychotic strength of chlorpromazine. Long-term animal studies have not been performed to assess the carcinogenic potential of promethazine, nor are there other animal or human data concerning carcinogenicity, mutagenicity, or impairment of fertility with this drug. Promethazine hydrochloride, a phenothiazine derivative, is chemically designated as ()-10-[2-(Dimethylamino)propyl] phenothiazine monohydrochloride. Drowsiness, dizziness, headache, upset stomach, nausea, constipation, or dry mouth may occur. Because of the potential for promethazine to reverse epinephrine's vasopressor effect, epinephrine should NOT be used to treat hypotension associated with promethazine overdose. Do not double the dose to catch up. Administration of phenylephrine to patients in late pregnancy or labor may cause fetal anoxia or bradycardia by increasing contractility of the uterus and decreasing uterine blood flow. Dosage must be individualized. promethazine/dextromethorphan oral syrup (6.25mg/15mg)/5mL Cough Temporary relief of cough and upper respiratory tract symptoms associated with allergy or the common cold 5 mL (6.25 mg/15 mg). QUALITEST PHARMACEUTICALS Cardiovascular Hypertension (see "WARNINGS"). Dermatologic Dermatitis, photosensitivity, urticaria. Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood/immune system problems (such as bone marrow depression), breathing problems (such as asthma, emphysema, sleep apnea), diabetes, glaucoma, heart problems (such as angina, irregular heartbeat), high blood pressure, liver problems, seizure, stomach/bowel problems (such as ulcer, blockage), overactive thyroid (hyperthyroidism), difficulty urinating (such as due to enlarged prostate). Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Atropine-like signs and symptoms dry mouth, fixed dilated pupils, flushing, as well as gastrointestinal symptoms, may occur. Diazepam may be used to control convulsions. Specific studies to test the action of the drug on parturition, lactation, and development of the animal neonate were not done, but a general preliminary study in rats indicated no effect on these parameters. Excessively large dosages of antihistamines, including promethazine hydrochloride, in pediatric patients may cause sudden death (see OVERDOSAGE). A study in rabbits indicated that continued moderate overexposure to phenylephrine (3 mg/day) during the second half of pregnancy (22nd day of gestation to delivery) may contribute to perinatal wastage, prematurity, premature labor, and possibly fetal anomalies; when phenylephrine (3 mg/day) was given to rabbits during the first half of pregnancy (3rd day after mating for seven days), a significant number gave birth to litters of low birth weight. Phenylephrine increases the work of the heart by increasing peripheral arterial resistance. Phenylephrine increases the work of the heart by increasing peripheral arterial resistance. Only in cases of extreme overdosage or individual sensitivity do vital signs including respiration, pulse, blood pressure, temperature, and EKG need to be monitored. The impairment may be amplified by concomitant use of other central nervous system depressants such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should either be eliminated or given in reduced dosage in the presence of promethazine HCl Before taking this medication, tell your doctor or pharmacist if you are allergic to promethazine or phenylephrine; or if you have any other allergies. PROMETHAZINE HYDROCHLORIDE AND PHENYLEPHRINE HYDROCHLORIDE SYRUP IS CONTRAINDICATED FOR USE IN PEDIATRIC PATIENTS LESS THAN TWO YEARS OF AGE (see WARNINGS Black Box Warning and Use In Pediatric Patients). Note that any depressant effects of promethazine are not reversed by naloxone. FDA pregnancy category C. It is not known whether Promethazine VC Plain will harm an unborn baby. The Promethazine VC brand name has been discontinued in the U.S. Promethazine is an antihistamine that reduces the effects of natural chemical histamine in the body. Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing in the urine. Each 5 mL (one teaspoonful), for oral administration contains: Promethazine hydrochloride 6.25 mg; phenylephrine hydrochloride 5 mg. Alcohol 7%. This survey is being conducted by the WebMD marketing sciences department. Drug The impairment may be amplified by concomitant use of other central nervous system depressants such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should either be eliminated or given in reduced dosage in the presence of promethazine HCl (see PRECAUTIONS - Information For Patients and Drug Interactions). An increase in blood glucose has been reported in patients receiving promethazine. Synergistic adrenergic response. Severe hypotension usually responds to the administration of norepinephrine or phenylephrine. Attention should be given to the re-establishment of adequate respiratory exchange through provision of a patent airway and institution of assisted or controlled ventilation. Do not use this product to make a child sleepy. Take this medication by mouth with or without food as directed by your doctor, usually every 4 to 6 hours as needed. Acidosis and electrolyte losses should be corrected. Promethazine may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery. Promethazine should be used with caution in patients with bone marrow depression. Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Taking certain products together can cause you to get too much of a certain drug. Drug Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Promethazine hydrochloride is used to treat a wide variety of infections caused by bacteria. They may faint. IT IS RECOMMENDED THAT THE LOWEST EFFECTIVE DOSE OF PROMETHAZINE HYDROCHLORIDE BE USED IN PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDER AND CONCOMITANT ADMINISTRATION OF OTHER DRUGS WITH RESPIRATORY DEPRESSANT EFFECTS BE AVOIDED. Excessive amounts of promethazine HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain. . (See WARNINGS Promethazine;Neuroleptic Malignant Syndrome.). Promethazine suppository, promethazine dm cough syrup for sale online, order promethazine for sleep, where to buy wockhardt promethazine plain, tris lean, how much is a line of lean, green promethazine codeine, promethazine abuse, high tech syrup, wockhardt cough syrup, woc lean, promethazine . US residents can call their local poison control center at 1-800-222-1222. Advertise; About Crumbs; Meet The Team; Competitions; Submit your event; Job board; Search. We comply with the HONcode standard for trustworthy health information. What conditions does Promethazine VC Plain Syrup treat? Caution should be exercised when promethazine and phenylephrine is administered to a nursing woman. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Generic name: phenylephrine and promethazine [fen-ill-EFF-rin-and-pro-MEH-thah-zeen] Use sunscreen and wear protective clothing when outdoors. prednisone, fluticasone nasal, montelukast, cetirizine, promethazine, Benadryl, diphenhydramine, Zyrtec, chlorpheniramine, Promethazine DM. The diagnostic evaluation of patients with this syndrome is complicated. POSTMARKETING CASES OF RESPIRATORY DEPRESSION, INCLUDING FATALITIES, HAVE BEEN REPORTED WITH USE OF PROMETHAZINE HYDROCHLORIDE IN PEDIATRIC PATIENTS LESS THAN 2 YEARS OF AGE. Cardiac output is decreased slightly. WebMD does not provide medical advice, diagnosis or treatment. In addition to its antihistaminic action, it provides clinically useful sedative and antiemetic effects. Brand names: Phenergan VC, Promethazine VC Plain The main effect of phenylephrine on the heart is bradycardia; it produces a positive inotropic effect on the myocardium in doses greater than those usually used therapeutically. Informe a su mdico acerca de todos los frmacos, vitaminas y suplementos de hierbas que est utilizando, para que el mdico pueda ayudarle a prevenir o manejar interacciones de frmacos. Store at room temperature away from moisture and heat. Patients should be advised to report any involuntary muscle movements. Phenylephrine should be used with caution in patients taking diet preparations, such as amphetamines or phenylpropanolamine, because synergistic adrenergic effects could result in serious hypertensive response and possible stroke. USUAL DOSAGE: See accompanying package insert. Promethazine Promethazine is a first-generation antihistamine and antiemetic used to treat allergies, insomnia, and nausea. It has a molecular weight of 203.67, a molecular formula of C9H13NO2HCI, and the following structural formula: Promethazine is a phenothiazine derivative which differs structurally from the antipsychotic phenothiazines by the presence of a branched side chain and no ring substitution. Signs and symptoms of overdosage with promethazine HCl range from mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Cardiovascular Increased or decreased blood pressure, tachycardia, bradycardia, faintness. You may report side effects to FDA at 1-800-FDA-1088. Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. An increase in blood glucose has been reported in patients receiving promethazine. PROMETHAZINE HYDROCHLORIDE SHOULD NOT BE USED IN PEDIATRIC PATIENTS LESS THAN 2 YEARS OF AGE BECAUSE OF THE POTENTIAL FOR FATAL RESPIRATORY DEPRESSION. Following oral administration or topical application of phenylephrine to the mucosa, constriction of blood vessels in the nasal mucosa relieves nasal congestion associated with allergy or head colds. The treatment of overdosage with promethazine and phenylephrine is essentially symptomatic and supportive. Fast buy promethazine codeine vs hydrocodone syrup - VISA. and untreated or inadequately treated extrapyramidal signs and symptoms (EPS). Promethazine is used to treatuffy nose by blocking the production of chemicals in the air that cause the feeling of tickle, run and tickle-shaped pain (worchitis) which is affected by colds and may be caused by sneezing or coughing or by the drying effects of the weather, wind or by being poorly air-conditioned. Medically reviewed by Drugs.com. CAUTION SHOULD BE EXERCISED WHEN ADMINISTERING PROMETHAZINE PRODUCTS TO PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDER BECAUSE OF THE POTENTIAL FOR FATAL RESPIRATORY DEPRESSION. The main effect of phenylephrine on the heart is bradycardia; it produces a positive inotropic effect on the myocardium in doses greater than those usually used therapeutically. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. Limited experience with dialysis indicates that it is not helpful. Headache may be a symptom of hypertension. PROMETHAZINE PRODUCTS ARE CONTRAINDICATED FOR USE IN PEDIATRIC PATIENTS LESS THAN TWO YEARS OF AGE. Atropine-like signs and symptoms dry mouth, fixed dilated pupils, flushing, as well as gastrointestinal symptoms, may occur. Symptoms of overdose may include: confusion, slowed breathing, seizure. Hallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine hydrochloride in pediatric patients. Phenylephrine can cause a decrease in cardiac output, and extreme caution should be used when administering the drug parenterally or orally to patients with arteriosclerosis, to elderly individuals, and/or to patients with initially poor cerebral or coronary circulation. We are still located on the same block but now next to AT&T. (415) 474-5321: . Daily doses of 25 mg/kg intraperitoneally have been found to produce fetal mortality in rats. Phenylephrine increases resistance and, to a lesser extent, decreases capacitance of blood vessels. The pharmacologic action of phenylephrine is terminated at least partially by uptake of the drug into tissues. It is not known whether promethazine or phenylephrine are excreted in human milk. It is thought that this configuration is responsible for its relative lack (1/10 that of chlorpromazine) of dopamine antagonist properties. Do not give Promethazine VC Plain to a child younger than 2 years old. The following laboratory tests may be affected in patients who are receiving therapy with promethazine hydrochloride. Phenylephrine with diet preparations, such as amphetamines or phenylpropanolamine. Men with symptomatic, benign prostatic hypertrophy can experience urinary retention when given oral nasal decongestants. There are no adequate and well-controlled studies of promethazine in pregnant women. Promethazine is as an antihistamine used to treat breathing difficulties including nausea, vomiting and runny nose. (See WARNINGS Promethazine; Respiratory Depression. Promethazine dm 6.25 15 mg 5ml para que sirve Visa. Avoid analeptics which may cause convulsions. Stimulation may be evident, especially in children and geriatric patients. Promethazine can help you stay awake, but it usually comes with side effects like. Promethazine administered to a pregnant woman within two weeks of delivery may inhibit platelet aggregation in the newborn. Data sources include IBM Watson Micromedex (updated 2 Dec 2022), Cerner Multum (updated 7 Dec 2022), ASHP (updated 11 Nov 2022) and others. Dilated blood vessels can cause nasal congestion (stuffy nose). This medication may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS). Keep tightly closed. Medically reviewed by Drugs.com on Oct 19, 2022. Promethazine VC is used to treat symptoms of the common cold, such as a stuffy nose and cough. Artificially sweetened liquid medicine may contain phenylalanine. Promethazine may lead to potentially fatal respiratory depression. Excessive amounts of promethazine HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain. If generic versions of this product have been approved by the FDA, there may be generic equivalents available. Keep all medications away from children and pets. Phenylephrine with prior administration of propranolol or other -adrenergic blockers. . Promethazine is an antihistamine that relieves watery eyes, itchy eyes/nose/throat, runny nose, and sneezing. Do not take this medication for several days before you have an allergy test because results can be affected. ), Other Angioneurotic edema. Concomitant use of other agents with anticholinergic properties should be undertaken with caution. Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Convulsions may rarely occur. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmias). Select a condition to view a list of medication options. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Tell your doctor or pharmacist if you are taking other products such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as cetirizine, diphenhydramine). Since recurrences of NMS have been reported with phenothiazines, the reintroduction of promethazine HCl should be carefully considered. Excessively large dosages of antihistamines, including promethazine hydrochloride, in pediatric patients may cause sudden death (see OVERDOSAGE). Older adults may be more sensitive to the effects of the drug, especially dizziness, drowsiness, confusion, constipation, trouble urinating, trouble sleeping, or fast/irregular heartbeat. Copyright 1996-2022 Cerner Multum, Inc. Last updated on Mar 1, 2021. Phenylephrine with diet preparations, such as amphetamines or phenylpropanolamine. Drug EffectSynergistic adrenergic response. Daily doses of 25 mg/kg intraperitoneally have been found to produce fetal mortality in rats. Do not store in the bathroom. PROMETHAZINE HYDROCHLORIDE AND PHENYLEPHRINE HYDROCHLORIDE ORAL SOLUTION IS CONTRAINDICATED FOR USE IN PEDIATRIC PATIENTS LESS THAN TWO YEARS OF AGE (see WARNINGS Black Box Warning and Use In Pediatric Patients). m.j.flower710@gmail.com Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6.25 and 12.5 mg/kg of promethazine HCl. Talk to the doctor or pharmacist before giving other cough-and-cold medication that might contain the same or similar ingredients that might also affect breathing. A very serious allergic reaction to this drug is rare. Respiratory Asthma, nasal stuffiness, respiratory depression (potentially fatal) and apnea (potentially fatal). Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as confusion, hallucinations), ringing in the ears, shaking (tremors), difficulty urinating, vision changes (such as blurred/double vision), easy bruising/bleeding, uncontrolled behaviors/movements (such as fixed upward stare, neck twisting, tongue movements). Phenylephrine with tricyclic antidepressants. Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur. Another study showed that phenylephrine was associated with anomalies of aortic arch and with ventricular septal defect in the chick embryo. Effect Sedation, somnolence, blurred vision, dizziness; confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. Ventricular premature beats and short paroxysms of ventricular tachycardia may also occur. Signs and symptoms of overdosage with phenylephrine include hypertension, headache, convulsions, cerebral hemorrhage, and vomiting. Administration of phenylephrine to patients in late pregnancy or labor may cause fetal anoxia or bradycardia by increasing contractility of the uterus and decreasing uterine blood flow. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have: jaundice (yellowing of the skin or eyes); sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing; uncontrollable movements of your eyes, lips, tongue, face, arms, or legs; or. Store at room temperature away from light and moisture. Promethazine is an H1 receptor blocking agent. May cause acute hypertensive crisis. PROMETHAZINE VC- promethazinehydrochloride and phenylephrine hydrochloridesyrup If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Drugs having anticholinergic properties should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder-neck obstruction. It was once widely used as an antipsychotic, although it is not now generally used for this purpose. Dilated blood vessels can cause nasal congestion (stuffy nose). Things to remember when you fill your prescription. Many people using this medication do not have serious side effects. A study of the effects of adrenergic drugs on ovum transport in rabbits indicated that treatment with phenylephrine did not alter incidence of pregnancy; the number of implantations was significantly reduced when high doses of the drug were used. Store at 20-25C (68-77F) [see USP Controlled Room Temperature]. This is not a complete list of possible side effects. Promethazine VC Plain may also be used for purposes not listed in this medication guide. Do not give more often than prescribed. Best $0.72 x tablet promethazine 25 mg cryptocurrency. Promethazine 25 mg boxing 90 pills Promethazine syrup mfg dm with eCheck. Animal reproduction studies have not been conducted with the drug combinationpromethazine and phenylephrine. Overnight shipping promethazine vc codeine red syrup in jack what you should. Promethazine affects the body's ability to regulate inflammation, alertness, and pain control. Cardiovascular Hypertension (see " WARNINGS"). Nervous System Restlessness, anxiety, nervousness, and dizziness. Promethazine caplets (pantoprazole) is used to prevent nausea and vomiting in people 7 years and older. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Get medical help right away if you have any very serious side effects, including: slow/shallow breathing, seizure. . Because phenylephrine is an adrenergic agent, it should be given with caution to patients with thyroid diseases, diabetes mellitus, and heart disease or those receiving tricyclic antidepressants. Phenylephrine with prior administration of monoamine oxidase inhibitors (MAOI). Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever and primary central nervous system (CNS) pathology. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. Each 5 mL (one teaspoonful) contains Promethazine (Promethazine VC Plain) hydrochloride 6.25 mg, Promethazine VC Plain hydrochloride 5 mg, and alcohol 7 percent, and is available in bottles of 4 fluid ounce (118 mL), 8 fluid ounce (237 mL), one pint (473 mL) and one gallon (3785 . Ventricular premature beats and short paroxysms of ventricular tachycardia may also occur. Who should not take Promethazine VC Plain Syrup? Other Precordial pain, respiratory distress, tremor, and weakness. Promethazine VC Plain may cause blurred vision or impair your thinking or reactions. Promethazine hydrochloride and phenylephrine hydrochloride oral solution should be used with caution in pediatric patients 2 years of age and older (see WARNINGS Use In Pediatric Patients). Carefully measure the dose using a special measuring device/spoon. It should be used with caution in persons with seizure disorders or in persons who are using concomitant medications, such as narcotics or local anesthetics, which may also affect seizure threshold. Long-term animal studies have not been performed to assess the carcinogenic potential of phenylephrine, nor are there other animal or human data concerning mutagenicity. The product's dosage form is solution and is administered via oral form. Promethazine was nonmutagenic in the Salmonella test system of Ames. During pregnancy, this medication should be used only if clearly needed. Swelling of your tonsils and mouth Change of sleep habits Dizziness Fast or pounding heartbeats Dizziness or fainting spells stop using chlorpromazine and call your doctor or right away if you think youve taken too much promethazine. Promethazine may increase, prolong, or intensify the sedative action of other central nervous system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving promethazine HCl. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine. I work for a publishers para que se utiliza atarax 25 mg Anthony Weiner has dropped to fourth place among Democrats seeking to be New York City mayor after admitting . A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Promethazine hydrochloride and phenylephrine hydrochloride syrup is contraindicated for children under 2 years of age (see WARNINGS Black Box Warning and Use In Pediatric Patients). Do not take extra medicine to make up the missed dose. Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing in the urine. Canada residents can call a provincial poison control center. It has a molecular weight of 203.67, a molecular formula of C 9H 13NO 2HCI, and the following structural formula: Promethazine is a phenothiazine derivative which differs structurally from the antipsychotic phenothiazines by the presence of a branched side chain and no ring substitution. Some products (including some long-acting tablets/capsules) are not recommended for use in children younger than 12 years. In the US - Call your doctor for medical advice about side effects. THE EXTRAPYRAMIDAL SYMPTOMS WHICH CAN OCCUR SECONDARY TO PROMETHAZINE HYDROCHLORIDE ADMINISTRATION MAY BE CONFUSED WITH THE CNS SIGNS OF UNDIAGNOSED PRIMARY DISEASE, e.g., ENCEPHALOPATHY OR REYE'S SYNDROME. Neuroleptic malignant syndrome (potentially fatal) has also been reported. Caution should be exercised when promethazine and phenylephrine is administered to a nursing woman. Check the medication label if you have phenylketonuria (PKU). Store at 20-25C (68-77F) [see USP Controlled Room Temperature]. Promethazine caplets (pantoprazole) can be taken by adults and children under 7 years old. In pediatric patients who are acutely ill associated with dehydration, there is an increased susceptibility to dystonias with the use of promethazine HCl. ANTIEMETICS ARE NOT RECOMMENDED FOR TREATMENT OF UNCOMPLICATED VOMITING IN PEDIATRIC PATIENTS, AND THEIR USE SHOULD BE LIMITED TO PROLONGED VOMITING OF KNOWN ETIOLOGY. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. Do not take for longer than 7 days in a row. Promethazine (promethazine) 25 mg pkge. Phenylephrine is irregularly absorbed from and readily metabolized in the gastrointestinal tract. Otherwise, call a poison control center right away. Effect EffectCardiac pressor response potentiated. Men with symptomatic, benign prostatic hypertrophy can experience urinary retention when given oral nasal decongestants. Phenylephrine has no effect on -adrenergic receptors of the bronchi or peripheral blood vessels. Hematologic Leukopenia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis. Phenylephrine with atropine sulfate. In children 2 years and older, carefully follow the doctor's directions to use the lowest effective dose. Drug Promethazine hydrochloride, a phenothiazine derivative, is chemically designated as ()-10-[2-(Dimethylamino)propyl] phenothiazine monohydrochloride. Their pupils will be constricted. Anaheim, CA, Set id: b00b296d-6c34-48c8-9cfb-71ccc5c9a908, PROMETHAZINE HYDROCHLORIDE AND PHENYLEPHRINE HYDROCHLORIDE SYRUP IS CONTRAINDICATED FOR USE IN PEDIATRIC PATIENTS LESS THAN TWO YEARS OF AGE (, Promethazine hydrochloride and phenylephrine hydrochloride syrup is contraindicated for children under 2 years of age (, promethazinehydrochloride and phenylephrine hydrochloride syrup. Promethazine should be used cautiously in persons with cardiovascular disease or impairment of liver function. It belongs to the class of non-steroidal anti-inflammatory drugs (nsaids) as well as an antihistamine. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache or skin rash. It has a molecular weight of 320.88, a molecular formula of C 17H 20N 2SHCI, and the following structural formula: Phenylephrine hydrochloride is a sympathomimetic amine salt which is chemically designated as (-)-m-Hydroxy--[(methylamino)methyl] benzyl alcohol hydrochloride. Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems. 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